Controlled reversible aggregation of thermoresponsive polymeric nanoparticles by interfacial Diels-Alder reaction

Immuno-polymeric nanoparticles by Diels-Alder chemistry.

Asymmetric Catalysis of Diels–Alder Reaction

The Diels–Alder (DA) reaction (or “diene synthesis”) between a diene and a dienophile generates two s bonds stereoselectively and up to four chiral centers in a single step to afford six-membered cyclic compounds. This cycloaddition reaction named after Professor Otto Paul Hermann Diels (1876–1954) and his student Kurt Alder (1902–1958) was discovered in 1928 during studies on the reaction of b...

The Diels-Alder Reaction: an Update

In this update on the Diels-Alder reaction we would like to present an overview on how this very important reaction has progressed in the last decade, since the last spate of monographs and reviews appeared in the literature, and which deal with the reaction in the overall sense. Initially we present the Diels-Alder reaction in a generalised form, much as discovered over seventy years ago, so t...

Aqueous Ti(IV)-catalyzed Diels-Alder reaction.

The aqueous Diels-Alder reaction of 1,3-cyclohexadiene with 1,4-benzoquinone was compared and contrasted to the same reaction catalyzed with Flextyl P, a novel Ti(IV) performance catalyst. The catalyst improved conversion by 22% versus the uncatalyzed reaction and represents a rare example of a Ti(IV) catalyzed Diels-Alder reaction in water.

Asymmetric hetero-Diels-Alder reaction catalyzed by dirhodium(II) carboxamidates.

Chiral dirhodium(II) carboxamidates are highly efficient catalysts for reactions between a variety of aldehydes and activated dienes. Catalyst loadings as low at 0.01 mol % have been realized with enantioselectivities up to 97%. Kinetic investigations reveal a pronounced electronic influence on the rate of the hetero-Diels-Alder reaction with a Hammett rho value of +1.9 (versus sigma(+)). Inhib...